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12021Importance trial: A provisional study-design of a singlecenter, phase II, double-blinded, placebo-controlled, randomized, 4-week study to compare the efficacy and safety of intranasal esketamine in chronic opioid refractory painFernandes, M.; Schelotto, M.; Doldi, P. M.; Milani, G.; Manzano, A. A.; Perera Valdivia, D.; Winter Matos, Alexandra Marie; Hamdy Abdelrahim, Y.; Hamad Bek, S. A.; Benítez, B. K.; Romanelli Tavares, V. L.; Basendwah, A. M.; Albuquerque Sousa, L. H.; Faria Xavier, N.; Zertuche Maldonado, T.; Toyomi de Oliveira, S.; Chaker, M.; Menon Miyake, M.; Uygur Kucukseymen, E.; Waqar, K.; Alkhozondar, O. M. J.; Bernardo da Silva, R.; Droppelmann, G.; Vaz de Macedo, A.; Nakamura, R.; Fregni, F.Journal Article