Full text [open access]
Journal Article
Influence of experimental alcoholism on the repair process of bone defects filled with beta-tricalcium phosphate
Torres Pomini, K.
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Cestari, T. M.
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Santos Germán, Iris Jasmin
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De Oliveira Rosso, M. P.
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Barbosa de Oliveira Gonçalves, J.
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Vieira Buchaim, D.
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Pereira, M.
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Andreo, J. C.
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Rosa Júnior, G. M.
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Botteon Della Coletta, B.
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Tadashi Cosin Shindo, J. V.
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Leone Buchaim, R.
| Fecha de publicación | Revista | DOI |
2019 |
Resumen
This study evaluated the effect of ethanol on the repair in calvaria treated with beta-tricalcium phosphate (β-TCP). Forty rats were distributed into 2 groups: Water group (CG, n = 20) and Alcohol Group (AG, n = 20), which received 25% ethanol ad libitum after an adaptation period of 3 weeks. After 90 days of liquid diet, the rats were submitted to a 5.0 mm bilateral craniotomy in the parietal bones; the left parietal was filled with β-TCP (CG-TCP and AG-TCP) and the contralateral only with blood clot (CG-Clot and AG-Clot). The animals were killed after 10, 20, 40 and 60 days. The groups CG-Clot and AG-Clot showed similar pattern of bone formation with a gradual and significant increase in the amount of bone in CG-Clot (22.17 ± 3.18 and 34.81 ± 5.49) in relation to AG-Clot (9.35 ± 5.98 and 21.65 ± 6.70) in periods of 20–40 days, respectively. However, in the other periods there was no statistically significant difference. Alcohol ingestion had a negative influence on bone formation, even with the use of β-TCP, exhibiting slow resorption and replacement by fibrous tissue, with 16% of bone formation within 60 days in AG-TCP, exhibiting immature bone tissue with predominance of disorganized collagen fibers. Defects in CG-TCP showed bone tissue with predominance of lamellar arrangement filling 39% of the original defect. It can be concluded that chronic ethanol consumption impairs the ability to repair bone defects, even with the use of a β-TCP biomaterial.