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Title: Influence of experimental alcoholism on the repair process of bone defects filled with beta-tricalcium phosphate
Autores: Torres Pomini, K.
Cestari, T. M.
Santos Germán, Iris Jasmin
De Oliveira Rosso, M. P.
Barbosa de Oliveira Gonçalves, J.
Vieira Buchaim, D.
Pereira, M.
Andreo, J. C.
Rosa Júnior, G. M.
Botteon Della Coletta, B.
Tadashi Cosin Shindo, J. V.
Leone Buchaim, R.
Researchers (UNIBE): Santos Germán, Iris Jasmin 
Affiliations: Facultad de Ciencias de la Salud 
Research area: Ciencias de la Salud
Keywords: Bone regeneration; Bone repair; Alcohol; Biomaterial
Issue Date: 2019
Publisher: Elsevier
Source: Drug and Alcohol Dependence, 197, 315-325
Journal: Drug and Alcohol Dependence 
Issue: 197
Start page: 315
End page: 325
This study evaluated the effect of ethanol on the repair in calvaria treated with beta-tricalcium phosphate (β-TCP). Forty rats were distributed into 2 groups: Water group (CG, n = 20) and Alcohol Group (AG, n = 20), which received 25% ethanol ad libitum after an adaptation period of 3 weeks. After 90 days of liquid diet, the rats were submitted to a 5.0 mm bilateral craniotomy in the parietal bones; the left parietal was filled with β-TCP (CG-TCP and AG-TCP) and the contralateral only with blood clot (CG-Clot and AG-Clot). The animals were killed after 10, 20, 40 and 60 days. The groups CG-Clot and AG-Clot showed similar pattern of bone formation with a gradual and significant increase in the amount of bone in CG-Clot (22.17 ± 3.18 and 34.81 ± 5.49) in relation to AG-Clot (9.35 ± 5.98 and 21.65 ± 6.70) in periods of 20–40 days, respectively. However, in the other periods there was no statistically significant difference. Alcohol ingestion had a negative influence on bone formation, even with the use of β-TCP, exhibiting slow resorption and replacement by fibrous tissue, with 16% of bone formation within 60 days in AG-TCP, exhibiting immature bone tissue with predominance of disorganized collagen fibers. Defects in CG-TCP showed bone tissue with predominance of lamellar arrangement filling 39% of the original defect. It can be concluded that chronic ethanol consumption impairs the ability to repair bone defects, even with the use of a β-TCP biomaterial.
DOI: 10.1016/j.drugalcdep.2018.12.031
Appears in Collections:Publicaciones del Área de Salud - Medicina
Publicaciones indexadas en Scopus / Web of Science

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