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Title: Hydroxychloroquine-induced bull's eye maculopathy
Autores: Pellerano, Fernando
Chahín G.
Leonor M. N.
Stern H.
Researchers (UNIBE): Pellerano, Fernando 
Affiliations: Facultad de Ciencias de la Salud 
Research area: Ciencias de la Salud
Issue Date: 2020
Publisher: Lancet Publishing Group
Source: The Lancet Rheumatology, 2(2), e120
Journal: The Lancet Rheumatology 
Volume: 2
Issue: 2
Start page: e120
A woman aged 28 years with systemic lupus erythematous and abnormal kidney function, treated with 4·5 mg/kg hydroxychloroquine daily for 15 years (cumulative dose 1369 g), presented with bilateral progressive central vision loss for 2 months. The patient had no known previous exposure to chloroquine. Best corrected visual acuity was 20/40 in her right eye and 20/30 in her left eye. Funduscopy showed a concentric hypopigmentation around both foveas (figure). Spectral domain optical coherence tomography of the macula revealed photoreceptor layer and retinal pigmented epithelium loss, and automated 24-2 visual fields showed bilateral central scotomas (figure). These findings were consistent with bull's eye maculopathy, a classic feature of advanced hydroxychloroquine toxicity. 3 months after medication was stopped, the patient's visual acuity had remained stable, and no other complaints were reported.
DOI: 10.1016/S2665-9913(19)30040-2
Appears in Collections:Publicaciones de la Facultad de Ciencias de la Salud

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