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Title: Peripheral artery disease as a risk factor for myocardial infarction
Autores: Pérez Mejias, E. L.
Mateo Faxas, S.
Tejeda Taveras, Nicole
Subhan Talpur, A.
Kumar, J.
Khalid, M
Aruwani, S. K.
Dua Khalid, D.
Khalid, H.
Memon, S.
Researchers (UNIBE): Tejeda Taveras, Nicole 
Affiliations: Facultad de Ciencias de la Salud 
Research area: Ciencias de la Salud
Keywords: Peripheral artery disease; Risk factor; Myocardial infarction; Association; Fatal myocardial infarction
Issue Date: 2021
Publisher: Cureus, Inc.
Source: Cureus, 13(6), e15655
Journal: Cureus 
Volume: 13
Issue: 6
Start page: e15655
Introduction: Atherosclerosis contributes to the underlying pathophysiology for peripheral arterial disease (PAD), coronary artery disease (CAD), and cerebrovascular disease. Several studies have been conducted to demonstrate PAD as a major risk factor for cardiovascular (CV) events, however, the regional data are limited. This study aims to highlight PAD as a major risk factor in CV events in a local setting.

Methods: In this longitudinal study, 400 hypertensive patients with a confirmed diagnosis of PAD were enrolled from the outpatient department of the cardiology unit. Diagnosis of PAD was made using the ankle brachial index (ABI). ABI less than 0.9 was labeled as participants with PAD. Another group of 400 without PAD was also enrolled as the control group from the outpatient department of cardiology unit. Patients were followed up for 12 months or for the development of myocardial infarction (MI).

Result: Participants with PAD had a significant increased risk of total MI events with a relative risk (RR) of 1.67 (confidence interval, CI 95%: 1.05-2.66; p-value: 0.02). The RR for fatal MI was 2.62 (CI 95%: 0.94-7.29; p-value: 0.06) compared to the participants without PAD, however, it was not significant.

Conclusion: This study has focused on the risk factors of PAD and has suggested that the patients who have any of the mentioned risk factors should be treated with caution under strict instructions given by doctors. A variety of treatment options is available, but the initial changes should be made in the lifestyle of these patients, making sure the risk factors are being treated.
DOI: 10.7759/cureus.15655
Appears in Collections:Publicaciones del Área de Salud - Medicina
Publicaciones indexadas en Scopus / Web of Science

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