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Title: Human T-Cell Lymphotropic Virus Type 1 and associated diseases in Latin America
Autores: Eusebio-Ponce, Emiliana
Candel, F. J.
Anguita, E.
Researchers (UNIBE): Eusebio-Ponce, Emiliana 
Affiliations: Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Research area: Ciencias de la Salud
Keywords: Human T-cell Lymphotropic Virus type 1; HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis; Adult T-Cell Leukaemia–Lymphoma; Latin America; Prevention; Breastfeeding; Epidemiology
Issue Date: 2019
Publisher: Wiley-Blackwell Publishing Ltd
Source: Tropical Medicine & International Health, 24(8), 934-953
Journal: Tropical Medicine and International Health 
Volume: 24
Issue: 8
Start page: 934
End page: 953
This narrative review, which is based on a systematic literature search following the PRISMA guidelines, provides a general overview of Human T-cell Lymphotropic Virus type 1 (HTLV-1) and associated diseases: Adult T-cell Leukaemia-Lymphoma (ATLL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in Latin America, focusing on epidemiology and prevention. Using the published information on HTLV-1, ATLL and HAM/TSP prevalence, we present comprehensive and accurate maps and tables, and developed an algorithm to assist in the prevention of HTLV-1 transmission through breastfeeding while considering socio-economic status. Latin America is an interesting scenario to study HTLV-1 because of the diverse origin of its population. Apart from the expected high prevalence in inhabitants of African ancestry, the presence of endemic foci affecting indigenous populations is particularly striking. ATLL prevention is the biggest challenge in this field. Most ATLL cases are transmitted through breastfeeding; thus, prevention methods to avoid ATLL in endemic countries have to be focused on this. In view of the high inequality in most Latin American countries, reduction in breastfeeding duration, freezing/thawing and pasteurisation of breastmilk can be suitable interventions in poor settings, considering that avoiding the risk of malnutrition and infant mortality must be the priority.
DOI: 10.1111/tmi.13278
Appears in Collections:Publicaciones del IMTSAG-UNIBE
Publicaciones indexadas en Scopus / Web of Science

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