Please use this identifier to cite or link to this item:
http://cris.unibe.edu.do/handle/123456789/313
DC Field | Value | Language |
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dc.contributor.author | González Mejías, Stephanie | - |
dc.date.accessioned | 2022-02-28T00:29:51Z | - |
dc.date.available | 2022-02-28T00:29:51Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Cureus 10(8), e3216 | - |
dc.identifier.uri | http://cris.unibe.edu.do/handle/123456789/313 | - |
dc.description.abstract | Asthma is a chronic respiratory condition that is characterized by reversible airflow obstruction. Interleukin-5 (IL-5) is involved in the pathophysiology of the disease and drugs targeting IL-5 have been studied for years as a possible treatment option for severe asthma. In this review, the authors searched PubMed for major drug therapies and clinical trials against IL-5. A total of 29 articles met the criteria for selection and were shortlisted; of these, 10 papers were on benralizumab, 14 on mepolizumab, and five on reslizumab. The three drugs proved to be safe and efficacious for patients with severe asthma, leading to decreased rates of asthma exacerbations, lowered levels of eosinophils, and improved pulmonary functions in various studies. Patients also reported an improvement in the quality of life. The side effects of these three drugs were mild and no deaths directly linked to the drug were reported. However, longer duration studies are required to draw firm and strong conclusions on the safety of these therapeutic agents. | en |
dc.language.iso | English | - |
dc.publisher | Cureus, Inc. | - |
dc.relation.ispartof | Cureus | - |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | - |
dc.subject | Ciencias de la Salud | - |
dc.title | A review of three new anti-interleukin-5 monoclonal antibody therapies for severe asthma | en |
dc.type | Review Article | - |
dc.rights.license | This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | - |
dc.identifier.doi | 10.7759/cureus.3216 | - |
dc.identifier.pmid | 30416896 | - |
dc.rights.holder | © 2018 Agumadu et al. | - |
dc.contributor.affiliation | Facultad de Ciencias de la Salud | - |
dc.identifier.pmcid | PMC6223665 | - |
dc.relation.issn | 2168-8184 | - |
dc.description.volume | 10 | - |
dc.description.issue | 8 | - |
dc.description.startpage | e3216 | - |
dc.subject.keywords | Asthma | en |
dc.subject.keywords | Monoclonal antibody | en |
dc.contributor.authors | Agumadu, V. C. | - |
dc.contributor.authors | Ramphul, K. | - |
dc.contributor.authors | González Mejías, Stephanie | - |
dc.contributor.authors | Sonaye, R. | - |
dc.contributor.authors | Sombans, S. | - |
dc.contributor.authors | Lohana, P. | - |
dc.typeofaccess | Open Access | - |
dc.contributor.affiliationinstitution | International University of the Health Sciences School of Medicine | - |
dc.contributor.affiliationinstitution | Shanghai Xin Hua Hospital | - |
dc.contributor.affiliationinstitution | Universidad Iberoamericana (UNIBE) | - |
dc.contributor.affiliationinstitution | Bharati Vidyapeeth Deemed University Medical College and Hospital | - |
dc.contributor.affiliationinstitution | Bharati Vidyapeeth Deemed University Medical College and Hospital | - |
dc.contributor.affiliationinstitution | Liaquat University of Medicine and Health Sciences | - |
dc.contributor.affiliationcountry | St. Kitts & Nevis | - |
dc.contributor.affiliationcountry | China | - |
dc.contributor.affiliationcountry | Dominican Republic | - |
dc.contributor.affiliationcountry | India | - |
dc.contributor.affiliationcountry | Pakistan | - |
dc.contributor.affiliationcountry | Pakistan | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Con texto completo | - |
item.openairetype | Review Article | - |
item.grantfulltext | open | - |
item.languageiso639-1 | English | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Facultad de Ciencias de la Salud | - |
crisitem.author.parentorg | Universidad Iberoamericana (UNIBE) | - |
Appears in Collections: | Publicaciones del Área de Salud - Medicina |
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1612428107.pdf | Full text [open acces] | 138.31 kB | Adobe PDF | View/Open |
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