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Title: Hypertension, diabetes mellitus, and cerebrovascular disease predispose to a more severe outcome of COVID-19
Autores: Ramphul, K.
Lohana, P.
Ramphul, Y.
Park, Y.
González Mejías, Stephanie
Kaur Dhillon, B.
Sombans, S.
Verma, R.
Researchers (UNIBE): González Mejías, Stephanie 
Affiliations: Facultad de Ciencias de la Salud 
Research area: Ciencias de la Salud
Keywords: COVID-19; SARS-CoV-2; Cerebrovascular disease; Coronavirus 2019; Diabetes Hypertension; Meta-analysis; Pooled analysis; Severity; Stroke
Issue Date: 2021
Publisher: Termedia Publishing House
Source: Archives of Medical Sciences. Atherosclerotic Diseases, 6, e30–e39
Journal: Archives of Medical Sciences. Atherosclerotic Diseases 
Volume: 6
Start page: e30
End page: e39
Introduction: The world is currently facing the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The total number of cases of coronavirus disease 2019 (COVID-19) is rising daily and no vaccine has yet been approved. While the pathophysiology behind the virus is still being studied, many possible several risk factors using small sample sizes have been found.

Material and methods: We conducted a pooled analysis using several databases such as Medline, Scopus, Wangfang, Web of Science, Research Square, medrxiv, and Google Scholar to identify studies reporting severe and non-severe groups of COVID-19 patients. The odds ratios as well as the 95% confidence intervals for hypertension, diabetes, and cerebrovascular disease leading to severe COVID-19 were calculated using R-software.

Results: Fifty-three articles were used for our analysis and they involved 30,935 confirmed cases of COVID-19 from several countries across the world. The odds ratio for severe COVID-19 in hypertensive patients, diabetics, and patients with a history of cerebrovascular disease was 2.58 (95% confidence interval (CI): 2.16-3.08, from 53 studies), 2.17 (95% CI: 1.72-2.74, from 44 studies), and 2.63 (95% CI: 1.80-3.85, from 25 studies), respectively.

Conclusions: Our analysis confirms that patients with hypertension, diabetes, or cerebrovascular disease are at a higher risk of a severe outcome of COVID-19. It is thus vital for physicians to identify the main risk factors for a severe outcome of this disease.
DOI: 10.5114/amsad.2021.105255
Appears in Collections:Publicaciones del Área de Salud - Medicina

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