Por favor, use este identificador para citar o enlazar este ítem: http://cris.unibe.edu.do/handle/123456789/348
Título : SARS-CoV-2 specific neutralizing antibodies in vaccinated and unvaccinated HIV-positive individuals in the Dominican Republic
Autores: Estrella Vargas, Michelle M.
Gordo Febo, Wilfredo M.
Jabier Frías, Maridania
Salas, R.
Sánchez Morfe, Nelissa
Cuevas Martínez, Paula
Mueses Jiménez, Sayira P.
Ruiz De León, Ingrid C.
Lora Rodríguez, Héctor J.
Cepeda-Marte, Jenny L.
Paulino-Ramírez, Robert
Investigadores (UNIBE): Estrella Vargas, Michelle M. 
Gordo Febo, Wilfredo M. 
Jabier Frías, Maridania 
Sánchez Morfe, Nelissa 
Cuevas Martínez, Paula 
Mueses Jiménez, Sayira P. 
Ruiz De León, Ingrid C. 
Lora Rodríguez, Héctor J. 
Cepeda-Marte, Jenny L. 
Paulino-Ramírez, Robert 
Afiliaciones : Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Área de investigación : Ciencias de la Salud
Fecha de publicación : 2022
Editorial : American Society of Tropical Medicine and Hygiene
Publicado en: American Journal of Tropical Medicine and Hygiene, 107(4) suppl., 147-148; 2022
Revista: The American Journal of Tropical Medicine and Hygiene 
Volumen : 107
Número : 4
Página de inicio : 147
Página final : 148
Conferencia : ASTMH 2022 Annual Meeting, October 30 - November 3, Seattle, WA
Resumen : 
Occurrence of COVID infection in high burden HIV countries has been observed and associated to chronic infections and variants emergence. In the Dominican Republic it is estimated 1% of the population living with HIV. The aim of this study was to evaluate specific SARS-CoV-2 neutralizing antibodies in PLWHIV in a HIV Clinic, and to determine the clinical characteristics of reported COVID-19. Blood samples were collected after informed consent was signed for SARS-CoV-2 neutralizing antibodies detection. Data was collected from March 2020-October 2021. All participants completed a questionnaire. Samples were analyzed using IchromaTM II using a cut-off index (COI) for fluorescent interpretation. A total of 213 participants fulfil the study inclusion criteria. Mean age was 31 years old (SD 14). SARS-CoV-2 neutralizing antibodies were detected in 75% of participants. None experienced severe COVID-19. Vaccination status with at least one dose was reported in 71% of participants. The most common symptoms reported were anosmia 69% (n=65), dysgeusia 65% (n=61) and cough 60% (n=56). The most frequent comorbidity was arterial hypertension 61% (n=43), and diabetes mellitus 10% (n=7). A weak negative correlation was found between antibody detection and immune status (CD4 counts/HIV viral loads), rho=-0.218, p < 0.05. Knowing the most frequent clinical manifestations of people with SARS-CoV-2 and living with HIV helps us to offer a timely diagnosis and avoid future complications. Detection of specific neutralizing antibodies in immunosuppressed and/or not virally suppressed will facilitate immunological comprehension of vaccine campaigns (including boosters) and other preventive interventions.
URI : http://cris.unibe.edu.do/handle/123456789/348
Aparece en las colecciones: Publicaciones del IMTSAG-UNIBE
Publicaciones indexadas en Scopus / Web of Science

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