Please use this identifier to cite or link to this item:
Title: Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean
Autores: Taylor-Salmon, E.
Hill, V.
Paul, L. M.
Koch, R. T.
Breban, M. I.
Chaguza, C.
Sodeinde, A.
Warren, J. L.
Bunch, S.
Cano, N.
Cone, M.
Eysoldt, S.
García, A.
Gilles, N.
Hagy, A.
Heberlein, L.
Jaber, R.
Kassens, E.
Colarusso, P.
Davis, A.
Baudin, S.
Rico, E.
Mejía-Echeverri, Á.
Scott, B.
Stanek, D.
Zimler, R.
Muñoz-Jordán, J. L.
Santiago, G. A.
Adams, L. E.
Paz-Bailey, G.
Spillane, M.
Katebi, V.
Paulino-Ramírez, Robert
Mueses Jiménez, Sayira P.
Peguero Jerez, Armando G.
Sánchez Morfe, Nelissa
Norman, F. F.
Galán, J. C.
Huits, R.
Hamer, D. H.
Vogels, C. B. F.
Morrison, A.
Michael, S. F.
Grubaugh, N. D.
Researchers (UNIBE): Paulino-Ramírez, Robert 
Mueses Jiménez, Sayira P. 
Peguero Jerez, Armando G. 
Sánchez Morfe, Nelissa 
Affiliations: Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Research area: Ciencias de la Salud
Issue Date: 2023
Source: medRxiv 2023.11.11.23298412; 2023
Journal: medRxiv 
Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands in the Caribbean have experienced more frequent outbreaks, and all four dengue virus (DENV) serotypes have been reported in the region, leading to hyperendemicity and increased rates of severe disease. However, there is significant variability regarding virus surveillance and reporting between islands, making it difficult to obtain an accurate understanding of the epidemiological patterns in the Caribbean. To investigate this, we used travel surveillance and genomic epidemiology to reconstruct outbreak dynamics, DENV serotype turnover, and patterns of spread within the region from 2009-2022. We uncovered two recent DENV-3 introductions from Asia, one of which resulted in a large outbreak in Cuba, which was previously under-reported. We also show that while outbreaks can be synchronized between islands, they are often caused by different serotypes. Our study highlights the importance of surveillance of infected travelers to provide a snapshot of local introductions and transmission in areas with limited local surveillance and suggests that the recent DENV-3 introductions may pose a major public health threat in the region.
Appears in Collections:Publicaciones del IMTSAG-UNIBE

Files in This Item:
File Description SizeFormat
2023.11.11.23298412v1.full.pdfPreprint full text [open access]8.14 MBAdobe PDFView/Open
Show full item record Recommend this item

Google ScholarTM






This item is licensed under a Creative Commons License Creative Commons