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Title: How did CariesCare International performed under pandemic conditions in children: 1-year multicenter single-group interventional study
Autores: Martignon, S.
Beltrán, E. O.
Douglas, G. V. A.
Newton, J. T.
Pitts, N. B.
Deery, C.
Carletto‐Körber, F. P. M.
Cifuentes, O. L.
Fortich, N.
Chavarria, N.
Echeverri, B.
Kuzmina, I.
Muller‐Bolla, M.
Osorio, J. R.
Ramos, K.
Sanjuán, J.
San-Martín, M.
Aldo Squassi
Villena, R.
Aïem, E.
Cáceres-Matta, S.
Marcela Carreño, L.
Cerezo, M. P.
Conrado, A.
Hermida, L.
Llamas, J. I.
Oña, J. A.
Sanabria, A.
Said, D.
Sarrazola, A.
Sorazabal, A.
Zelada, D.
Abreu-Placeres, Ninoska
Braga, M. M.
Lara, J. S.
Melo, P.
Areias, C.
Falabello de Luca, A. C.
Rubi Tello, A.
Yunes Fragoso, Paula M.
Martínez-Mier, E. A.
Ferreira Zandona, A.
Cortes, A.
Researchers (UNIBE): Abreu-Placeres, Ninoska 
Yunes Fragoso, Paula M. 
Affiliations: Centro de Investigación en Biomateriales y Odontología (CIBO) 
Centro de Investigación en Biomateriales y Odontología (CIBO) 
Research area: Ciencias de la Salud
Keywords: Caries detection/diagnosis/prevention; Caries treatment; Child dentistry; Pandemic; Aerosol-generating procedures; Remote consultation
Issue Date: 2024
Publisher: BioMed Central Ltd.
Source: BMC Oral Health [preprint under review], available at Research Square; 2024
Journal: BMC Oral Health 
Background: In 2020, CariesCare International (CCI) -derived from ICCMS- was plannedto be tested for caries-control effectiveness in children by means of a multicenter randomized clinical trial (RCT). Nevertheless, due to the pandemic, RCTs proved unfeasible and aerosol-generating procedures (AGP) were associated with a spread of COVID-19. Consequently, the study design required to be modified to a single-interventional study and CCI had to be adapted excluding AGP and reducing on-site consultation (CCI-adapted).

Objective: This 12-month multicenter single-group interventional study aimed at assessing the effect of a pandemic CCI-adapted protocol on caries control in children.

Methods: Twenty-one Latin American and European centers with n³20 3-8-year-old children per center were invited to participate; 17 obtained IRB and signed written informed consents. Trained examiners assessed at baseline (T0) and 1-year follow-up (T1y) (blind to the intervention): CCI-caries risk, oral-health-related practices; dmf/DMFS with ICDAS-merged-Epi visual caries severity and activity criteria; dental sepsis and toothache. Individual- and tooth-surface-level personalized care plan was then performed by dental practitioners previously trained in CCI-adapted. After 5 months, parents’ and dentists’ dental-care-process acceptance (Treatment Evaluation Inventory) was assessed. The one-year caries-control effect of CCI-adapted was assessed in terms of tooth-surface and individual-level caries-progression control; oral-health behavior improvement, and caries-care system acceptability.

Results: Sixteen centers finished the study (94.1%; Latin America: n=13; Europe: n=3), with 337 children (78.6%;mean age of 5.5±1.6 years). There was a T0 to T1y significant decrease (p<0.05) in the mean number of tooth surfaces with caries lesions (7.7±9.1 to 2.8±4.6), with active caries lesions (6.8±8.8 to 0.8±2.2), and a tooth-surface caries-progression control of 99.3%. In the majority of children there was a significant (p<0.05) control of: caries progression (79.5%), high-caries risk (86.6%), and non-adequate oral-health behavior (72.7%). There was a very high (parents) and a high-very high (dentists) acceptability of CCI.

Conclusion: Given the challenge of the pandemic, this single-group interventional CCI-adapted study showed one-year control of caries progression, caries risk, and high parents’ and dentists’ CCI acceptance.
Appears in Collections:Publicaciones del CIBO-UNIBE

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