Specific neutralizing antibody detection against chikungunya virus in HIV-positive and HIV-negative individuals, Dominican Republic 2014 [abstract]

Abstract

In April 2013, the Dominican Republic Ministry of Health confirmed the first autochthonous transmission of Chikungunya Virus (CHIKV). In 2014, EW51 recorded 537 628 suspected and 84 confirmed cases. The PAHO/WHO defined a confirmed case such as a suspected case with any positive specific CHIKV test (viral isolation, RT-PCR, IgM, or four-fold increase of CHIKV specific antibodies titters). The objective of this study was to measure the presence of IgM-specific neutralizing antibodies among HIV (+) individuals after clinical onset of symptoms during the 2014 outbreak in the Dominican Republic.