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Journal Article
Phenylketonuria: central nervous system and microbiome interaction
Herrera Morban, Demian Arturo
| Fecha de publicación | Revista | DOI |
2017 |
Resumen
Phenylketonuria (PKU) is an autosomal recessive inborn error of metabolism characterized by increased phenylalanine (Phe) levels causing an inadequate neurodevelopment; the treatment of PKU is a Phe-restricting diet, and as such it can modulate the intestinal microbiome of the individual, generating central nervous system secondary disturbances that, added to the baseline disturbance, can influence the outcome of the disease.