Please use this identifier to cite or link to this item: http://cris.unibe.edu.do/handle/123456789/261
Title: Evaluation of the use of an inorganic bone matrix in the repair of bone defects in rats submitted to experimental alcoholism
Autores: Santos Germán, Iris Jasmin
Torres Pomini, K.
Cestari Bighetti, A. C.
Andreo, J. C.
Bertoni Reis, C. H.
Shinohara, A. L.
Rosa Júnior, G. M.
De Bortoli Teixeira, D.
De Oliveira Rosso, M. P.
Vieira Buchaim, D.
Leone Buchaim, R.
Researchers (UNIBE): Santos Germán, Iris Jasmin 
Affiliations: Facultad de Ciencias de la Salud 
Research area: Ciencias de la Salud
Keywords: Alcohol; Alcoholism; Biomaterials; Bone repair
Issue Date: 2020
Publisher: MDPI Multidisciplinary Digital Publishing Institute
Source: Materials, 13(3), 695
Journal: Materials 
Volume: 13
Issue: 3
Start page: 695
Abstract: 
To assess the effects of chronic alcoholism on the repair of bone defects associated with xenograft. Forty male rats were distributed in: control group (CG, n = 20) and experimental group (EG, n = 20), which received 25% ethanol ad libitum after a period of adaptation. After 90 days of liquid diet, the rats were submitted to 5.0-mm bilateral craniotomy on the parietal bones, subdividing into groups: CCG (control group that received only water with liquid diet and the defect was filled with blood clot), BCG (control group that received only water with liquid diet and the defect was filled with biomaterial), CEG (alcoholic group that received only ethanol solution 25% v/v with liquid diet and the defect was filled with blood clot), and BEG (alcoholic group that received only ethanol solution 25% v/v with liquid diet and the defect was filled with biomaterial). In the analysis of body mass, the drunk animals presented the lowest averages in relation to non-drunk animals during the experimental period. Histomorphologically all groups presented bone formation restricted to the defect margins at 60 days, with bone islets adjacent to the BCG biomaterial particles. CEG showed significant difference compared to BEG only at 40 days (17.42 ± 2.78 vs. 9.59 ± 4.59, respectively). In the birefringence analysis, in early periods all groups showed red-orange birefringence turning greenish-yellow at the end of the experiment. The results provided that, regardless of clinical condition, i.e., alcoholic or non-alcoholic, in the final period of the experiment, the process of bone defect recomposition was similar with the use of xenograft or only clot.
URI: http://cris.unibe.edu.do/handle/123456789/261
DOI: 10.3390/ma13030695
Appears in Collections:Publicaciones de la Facultad de Ciencias de la Salud

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