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Title: Fibrin sealant derived from human plasma as a scaffold for bone grafts associated with photobiomodulation therapy
Autores: Torres Pominia, K.
Vieira Buchaim, D.
Andreo, J. C.
De Oliveira Rosso, M. P.
Botteon Della Coletta, B.
Santos Germán, Iris Jasmin
Cestari Bighetti, A. C.
Shinohara, A. L.
Rosa Júnior, G. M.
Tadashi Cosin Shindo, J. V.
Priori Alcalde, M.
Hungaro Duarte, M. A.
De Bortoli Teixeira, D.
Leone Buchaim, R.
Researchers (UNIBE): Santos Germán, Iris Jasmin 
Affiliations: Facultad de Ciencias de la Salud 
Research area: Ciencias de la Salud
Keywords: Bone generation; Bone repair; Biomaterial; Fibrin sealant; Photobiomodulation therapy; Low-level laser therapy
Issue Date: 2019
Publisher: MDPI Multidisciplinary Digital Publishing Institute
Source: International Journal of Molecular Sciences, 20(7), 1761
Journal: International Journal of Molecular Sciences 
Volume: 20
Issue: 7
Start page: 1761
Fibrin sealants derived from human blood can be used in tissue engineering to assist in the repair of bone defects. The objective of this study was to evaluate the support system formed by a xenograft fibrin sealant associated with photobiomodulation therapy of critical defects in rat calvaria. Thirty-six rats were divided into four groups: BC (n = 8), defect filled with blood clot; FSB (n = 10), filled with fibrin sealant and xenograft; BCPBMT (n = 8), blood clot and photobiomodulation; FSBPBMT (n = 10), fibrin sealant, xenograft, and photobiomodulation. The animals were killed after 14 and 42 days. In the histological and microtomographic analysis, new bone formation was observed in all groups, limited to the defect margins, and without complete wound closure. In the FSB group, bone formation increased between periods (4.3 ± 0.46 to 6.01 ± 0.32), yet with lower volume density when compared to the FSBPBMT (5.6 ± 0.45 to 10.64 ± 0.97) group. It was concluded that the support system formed by the xenograft fibrin sealant associated with the photobiomodulation therapy protocol had a positive effect on the bone repair process.
DOI: 10.3390/ijms20071761
Appears in Collections:Publicaciones del Área de Salud - Medicina
Publicaciones indexadas en Scopus / Web of Science

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