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Title: Pharmacologic therapy of obesity: mechanisms of action and cardiometabolic effects
Autores: Montan, P. D.
Sourlas, A.
Olivero García, Jiohanna M.
Silverio, D.
Guzmán, E.
Kosmas, K. E.
Researchers (UNIBE): Olivero García, Jiohanna M. 
Affiliations: Facultad de Ciencias de la Salud 
Research area: Ciencias de la Salud
Keywords: Obesity; Overweight; Orlistat; Phentermine/Topiramate; Lorcaserin; Naltrexone/Bupropion; Liraglutide; Cardiometabolic effects
Issue Date: 2019
Publisher: AME Publishing Company
Source: Annals of translational medicine, 7(16), 393
Journal: Annals of Translational Medicine 
Volume: 7
Issue: 16
Start page: 393
Obesity is a chronic, relapsing, multifactorial disease, which has become a serious threat to public health globally, as the worldwide prevalence of obesity increases exponentially over time. It has been well established that obesity is associated with multiple adverse cardiometabolic effects. Although lifestyle changes are the first line of therapy for obesity, these are often insufficient in attaining weight loss goals. Orlistat, phentermine/topiramate, lorcaserin, naltrexone/bupropion, and liraglutide are agents that have been approved for the treatment of obesity but their effects on cardiometabolic risk factors and outcomes have not been clearly elucidated. Given the detrimental repercussions of obesity on cardiometabolic health, there is a pressing clinical need to fully understand the effects of these agents beyond weight loss alone. Certain previous weight loss drugs have been withdrawn due to safety concerns and this underlines the need for more careful assessment of the effects of the various pharmacologic agents currently used for the treatment of obesity. This review aims to provide an overview of the mechanisms, efficacy, safety and cardiometabolic effects of the currently available pharmacologic agents for weight loss.
DOI: 10.21037/atm.2019.07.27
Appears in Collections:Publicaciones del Área de Salud - Medicina
Publicaciones indexadas en Scopus / Web of Science

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