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Title: A review of three new anti-interleukin-5 monoclonal antibody therapies for severe asthma
Autores: Agumadu, V. C.
Ramphul, K.
González Mejías, Stephanie
Sonaye, R.
Sombans, S.
Lohana, P.
Researchers (UNIBE): González Mejías, Stephanie 
Affiliations: Facultad de Ciencias de la Salud 
Research area: Ciencias de la Salud
Keywords: Asthma; Monoclonal antibody
Issue Date: 2018
Publisher: Cureus, Inc.
Source: Cureus 10(8), e3216
Journal: Cureus 
Volume: 10
Issue: 8
Start page: e3216
Asthma is a chronic respiratory condition that is characterized by reversible airflow obstruction. Interleukin-5 (IL-5) is involved in the pathophysiology of the disease and drugs targeting IL-5 have been studied for years as a possible treatment option for severe asthma. In this review, the authors searched PubMed for major drug therapies and clinical trials against IL-5. A total of 29 articles met the criteria for selection and were shortlisted; of these, 10 papers were on benralizumab, 14 on mepolizumab, and five on reslizumab. The three drugs proved to be safe and efficacious for patients with severe asthma, leading to decreased rates of asthma exacerbations, lowered levels of eosinophils, and improved pulmonary functions in various studies. Patients also reported an improvement in the quality of life. The side effects of these three drugs were mild and no deaths directly linked to the drug were reported. However, longer duration studies are required to draw firm and strong conclusions on the safety of these therapeutic agents.
DOI: 10.7759/cureus.3216
Appears in Collections:Publicaciones del Área de Salud - Medicina

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