Please use this identifier to cite or link to this item: http://cris.unibe.edu.do/handle/123456789/348
Title: SARS-CoV-2 specific neutralizing antibodies in vaccinated and unvaccinated HIV-positive individuals in the Dominican Republic
Autores: Estrella Vargas, Michelle M.
Gordo Febo, Wilfredo M.
Jabier Frías, Maridania
Salas, R.
Sánchez Morfe, Nelissa
Cuevas Martínez, Paula
Mueses Jiménez, Sayira P.
Ruiz De León, Ingrid C.
Lora, Héctor
Cepeda-Marte, Jenny L.
Paulino-Ramírez, Robert
Researchers (UNIBE): Estrella Vargas, Michelle M. 
Gordo Febo, Wilfredo M. 
Jabier Frías, Maridania 
Sánchez Morfe, Nelissa 
Cuevas Martínez, Paula 
Mueses Jiménez, Sayira P. 
Ruiz De León, Ingrid C. 
Lora, Héctor 
Cepeda-Marte, Jenny L. 
Paulino-Ramírez, Robert 
Affiliations: Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Instituto de Medicina Tropical y Salud Global (IMTSAG) 
Research area: Ciencias de la Salud
Issue Date: 2022
Publisher: American Society of Tropical Medicine and Hygiene
Source: American Journal of Tropical Medicine and Hygiene, 107(4) suppl., 147-148; 2022
Journal: The American Journal of Tropical Medicine and Hygiene 
Volume: 107
Issue: 4
Start page: 147
End page: 148
Conference: ASTMH 2022 Annual Meeting, October 30 - November 3, Seattle, WA
Abstract: 
Occurrence of COVID infection in high burden HIV countries has been observed and associated to chronic infections and variants emergence. In the Dominican Republic it is estimated 1% of the population living with HIV. The aim of this study was to evaluate specific SARS-CoV-2 neutralizing antibodies in PLWHIV in a HIV Clinic, and to determine the clinical characteristics of reported COVID-19. Blood samples were collected after informed consent was signed for SARS-CoV-2 neutralizing antibodies detection. Data was collected from March 2020-October 2021. All participants completed a questionnaire. Samples were analyzed using IchromaTM II using a cut-off index (COI) for fluorescent interpretation. A total of 213 participants fulfil the study inclusion criteria. Mean age was 31 years old (SD 14). SARS-CoV-2 neutralizing antibodies were detected in 75% of participants. None experienced severe COVID-19. Vaccination status with at least one dose was reported in 71% of participants. The most common symptoms reported were anosmia 69% (n=65), dysgeusia 65% (n=61) and cough 60% (n=56). The most frequent comorbidity was arterial hypertension 61% (n=43), and diabetes mellitus 10% (n=7). A weak negative correlation was found between antibody detection and immune status (CD4 counts/HIV viral loads), rho=-0.218, p < 0.05. Knowing the most frequent clinical manifestations of people with SARS-CoV-2 and living with HIV helps us to offer a timely diagnosis and avoid future complications. Detection of specific neutralizing antibodies in immunosuppressed and/or not virally suppressed will facilitate immunological comprehension of vaccine campaigns (including boosters) and other preventive interventions.
URI: http://cris.unibe.edu.do/handle/123456789/348
Appears in Collections:Publicaciones del IMTSAG-UNIBE

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